PLLA 200mg
A clearly defined identity with 200 mg per vial
INNOFill
PLLA BIOSTIMULATOR
A Deeper Change,
Refined Over Time
A PLLA-based biostimulator designed to reorganize the deeper structural foundation of the skin through collagen neogenesis and extracellular matrix remodeling.
For subcutaneous or deep dermal injection
THE ESSENCE OF TIME
Meaningful Change
Takes Shape Over Time.
Rather than delivering temporary bulk, it helps rebuild deep structural support within the skin. INNOFill PLLA is designed to stimulate collagen production and support natural, progressive improvement.
Four Principles Behind INNOFill
From product identity to treatment philosophy, each principle is built around structural change that evolves over time.
Collagen Activation
Centered on endogenous collagen stimulation
Structure-Oriented
Designed with deeper tissue support in mind
Cumulative Over Time
Focused on progressive change rather than instant volume
POLY-L-LACTIC ACID
Beyond Immediate Volume,
Structural Reorganization
INNOFill PLLA is designed with priority on collagen remodeling, tissue density, and facial support rather than immediate volumization.
Collagen InductionECM RemodelingTissue DensityProgressive Change
01 · COLLAGEN
Collagen Induction
Guides fibroblast activation and new collagen formation.
02 · DENSITY
Tissue Density Improvement
A structural approach that helps reorganize the extracellular matrix.
03 · SUPPORT
Facial Support Foundation
Considers the support logic of the deeper skin structure.
MECHANISM OF ACTION
Collagen Remodeling,
Beginning in the Deep Tissue
An INNOFill PLLA biostimulation approach that activates collagen, re-establishes tissue architecture, and gradually restores natural volume over time.
STEP 01Particle Distribution
Evenly distributed within the target tissue plane
STEP 02Localized Biological Response
Initiates a controlled tissue response
STEP 03Collagen Induction
Fibroblast activity and ECM remodeling
STEP 04Structural Reorganization
Improved tissue density and support architecture
PLLA VS PDLLA
Same Lactic Acid Family,
Different Molecular Architecture
Differences in stereochemical arrangement and crystallinity can influence water penetration, hydrolysis, and the time course of tissue response.
PLLAPDLLA
Stereochemical StructurePredominantly regular L-form arrangementMixed D/L-form arrangement
CrystallinitySemi-crystallineAmorphous
Degradation RateRelatively gradual hydrolysisPotentially faster hydrolysis
Tissue ResponseFavors a more sustained stimulation profileTends toward an earlier-phase response
Collagen DurabilityGeared toward long-term structural remodelingMore focused on mid-term tissue improvement
Actual clinical performance is also influenced by molecular weight, particle size and morphology, reconstitution concentration, injected volume, and treatment plane.
VISIBLE PROGRESS
Structural Change
Built Over Time
The effect extends beyond the immediate post-treatment phase: as collagen builds over time, the support architecture within the deeper tissue becomes progressively more organized.
Progressive Collagen Formation
Encourages collagen response along a natural treatment timeline.
Long-Term Tissue Remodeling
Addresses extracellular matrix renewal together with structural reorganization.
Natural Volume Recovery
Prioritizes harmonious volume recovery over immediate expansion.
Improved Density & Elasticity
Supports a firmer skin impression by improving the deeper support base.
BEFORE
Reduced Structural Support in Aging Skin
Lower collagen density · diminished structural support
REMODELING
INNOFill PLLA Biostimulation-Driven Structural Remodeling
Progressive collagen accumulation · improved structural support base
TREATMENT PROTOCOL
INNOFill PLLA
Treatment Guide
Preparation, reconstitution, and pre-treatment check
Product
INNOFill PLLA 200 mg / vial
Reconstitution
Approx. 8 mL sterile water • 2 mL lidocaine
Hydration Time
Minimum 30 minutes
Before Treatment
Check for clumping, sedimentation, or non-uniform dispersion
* Allow at least 30 minutes of hydration to form a uniform suspension, and consider sufficient pre-hydration for more stable particle dispersion.
FACE DESIGN PROTOCOL
Suggested Treatment Points
Temple
0.5–1.0 cc / side
Cannula, fanningAnterior Cheek / Midface
0.8–1.0 cc / side
Cannula, linear retrogradeLateral Cheek
1.0–1.5 cc / side
Cannula, fanningPerinasal Fold
0.3–0.5 cc / side
Superficial linear threadingMarionette Area
0.3–0.5 cc / side
Linear retrogradeJawline
0.5–1.0 cc / side
Cannula, linear threadingSubdermal to subcutaneous fat plane
25–27G cannula or 27–30G needle
Displayed volumes are for educational reference; actual treatment should be adjusted according to skin condition and dilution ratio
PRODUCT SPECIFICATION
Product Specifications
Product NameINNOFill
BrandAestyve
Key IngredientPoly-L-Lactic Acid (PLLA)
Strength200 mg / vial
FormLyophilized powder
StorageStore at room temperature (1–30°C), do not freeze
PLLA BIOSTIMULATOR
INNOFill PLLA
More than a change in volumeStructural Remodeling
Beginning in the Deeper Skin
※ This page is intended for informational purposes and is based on product materials and related literature.
※ Before use, please review the official IFU, product approvals, and applicable local regulations.